Pre-Conference Workshops
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Meg
Landis
,
Senior Principal Scientist,
Pfizer
Marc
Tesconi
,
Group Lead, Formulation Design,
Pfizer
What you will learn:
-
Stage-appropriate methods of measuring solubility
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Pitfalls in the interpretation of solubility data
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Solubility considerations for key formulation platforms, including peptides and prodrugs
How you will benefit:
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Gain appreciation for the limitations of various solubility measurement methods
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Gain insight to critically interpret and evaluate solubility data
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Discuss and learn about current industrial strategy and practice
Rene
Holm
,
Head, Preformulation,
H. Lundbeck
Discovery formulations are used in pharmacology studies, ADME, and toxicology evaluations. The challenge for the pharmaceutical scientist is to use the limited exciting physical chemical data, knowledge about general compound behavior and computer models to achieve a formulation strategy that is suited to meet the needs and demands for each of these studies and route of administration – and that’s with a very limited amount of compound available. In vivo experiments are typically conducted with enabling formulations to maximize exposure of frequently low aqueous soluble compounds.
You will learn:
- Discuss the importance in formulations for pharmacology, ADME
- The role of toxicology
- Options in solubilisation techniques and the obtained experience
You will benefit:
- How to judiciously choose solubilizing vehicles in order to meet the desired concentration levels
- Keeping the vehicle should still be inert both pharmacologically and toxicologically
- The usage of different formulation strategies may change along the discovery process
Dedong
Wu
,
Senior Research Scientist,
AstraZeneca
Wenzhan
Yang
,
Senior Scientist,
AstraZeneca
This workshop highlights Layer-by-Layer surface nanoassembly is a simple method allowing the design of multilayer architectures with nanometer precision. There is great potential for this technology to be adopted in drug delivery.
You will learn:
- Layer-by-layer nanoassembly
- Basic principles of the LbL technology
- Potential application of LbL in drug delivery
You will benefit:
- A case study of an emerging application to the nanocystals technique is the layer-by-layer coating technique applied to nanoparticles
- Exploring if coated nanoparticles will not only improve particle stability as well as offer the possibility of designing nanoparticle surfaces that can achieve controlled release and targeted delivery