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At Holm With Supersaturation and other Formulation Strategies
In this interview, Rene Holm, Head of Preformulation at Lundbeck, discusses supersaturation, formulation strategies, and his hopes for the future. Rene will be presenting at the next Improving Solubility Summit.

Acoustic Levitation
Scientists at the U.S. Department of Energy’s Argonne National Laboratory have discovered a way to use sound waves to levitate individual droplets of solutions containing different pharmaceuticals. Argonne's CJ Benson will present his findings at the next Improving Solubility Summit.

Simulation of Food Effect on Cilostazol Exposure in Human
This research whitepaper is from event sponsors, Simulations Plus Inc.

Food effect is usually attributed to increased solubility/dissolution rate and/or modulation of the intestinal first pass. Using the PBPKPlus™ module in GastroPlus™, we were able to accurately reproduce the nonlinear dose-dependent exposure of cilostazol in Japanese and Western populations (based on a typical 30-year old male and calculated Kps and clearance in silico and in vitro data). Therefore, in the absence of intravenous data, mechanistic simulations of oral doses can help to estimate fraction absorbed, first pass extraction in gut and liver, and therefore, bioavailability, under both fasted and fed conditions.
Models of Solubility in Simulated Gastrointestinal Fluids
This research whitepaper is from Conference sponsors, Simulations Plus Inc.

Using a diverse set of 160 drugs and drug-like compounds obtained from commercial sources, where equilibrium solubilities were measured in fasted state simulated intestinal fluid (FaSSIF), fed state simulated intestinal fluid (FeSSIF), and fasted state simulated gastric fluid (FaSSGF), the application of model-building methods in our ADMET Predictor™ software resulted in improved artificial neural network ensemble (ANNE) models that can accurately predict both aqueous and biorelevant solubility of compounds from chemical structure.

Novartis' Jenny Sheng on the Future of Solubilization
Poor solubility is an obvious barrier to advancing potentially efficacious drug candidates. In this interview Jennifer Sheng, Fellow at Novartis, discusses the most efficient approaches for measuring solubility, and why solubility remains a critical challenge in formulation development. Jenny will be speaking at the next Improving Solubility Summit.

Past Attendee List
Download now to view the past attendees of our portfolio of Improving Solubility Conferences.

Does the Future of Solubility Lie in HME?
Pharma IQ discusses Hot Melt Extrusion, which creates crystalline structures with finer particles. HME will be the focus of Anjali Angrawal’s presentation “Hot Melt Extrusion as Formulation Enabling Technology” at the 7th Annual Improving Solubility Summit. Anjali is principal research scientist at Boehringer Ingelheim.
Innovation Through Drug Delivery
The increasing demand for effective delivery of novel pharmaceuticals is driving growth in the drug delivery market. For example, using nanotechnology to overcome bioavailability challenges. This great article is compliment of our friends at PharmaVoice.com.
Looking at Solubility Solutions
About 40% of marketed drugs are thought to be poorly water soluble. Development efforts might have to be redoubled, however, because between 70 and 90% of drug candidates in the pipeline are believed to have low solubility.
Meeting the Challenges of Poorly Soluble Drug Compounds
These approaches have enabled Eurand to develop products comprising one or more controlled release bead populations of weakly basic actives for absorption throughout the GI tract” says Dr. Stephen Perrett, VP Portfolio Development, Eurand. Instead of simply discounting drug candidates that present difficulties in terms of solubility, such as in cases where compounds have no solubility or the dose is high relative to solubility, Eurand has developed several approaches that overcome the limits of aqueous media.

NanoCluster Technology and Microcapsule Approaches for Improved Dissolution and Solubilization
Read this novel approach to nanocluster technology and microcapsule approaches for improved dissolution and solubilization by Cory Berkland, Associate Professor, The University of Kansas from IQPC’s 2011’s Improving Solubility Conference.